Capítulo 1773: Chapter 1777: Where Is the Core Technology?
This discovery practically set the entire research institute ablaze!
The discovery of this polyrase seems to directly validate the commonalities between Parkinson’s and Alzheir’s in neurodegenerative diseases!
However, that’s not the main point.
The most crucial aspect is that there’s finally a breakthrough in the battle against Parkinson’s!
Even Chen Cang didn’t expect the lure of the enzy to be so powerful!
It directly led to the discovery of this culprit polyrase.
After the polyrase was discovered, all departnts began clinical research and various experintal work!
The pace of experintation was nearly exponential!
Everyone was imrsed in this breakthrough-like progress!
Tethys did not regret joining Chen Cang’s camp even a bit.
He believes that even Kang Xiding couldn’t achieve this, managing to isolate Poly(ADP-ribose) Polyrase-1!
This polyrase belongs to ribose polyrase, existing within mitochondria and ribosos in cells, and it’s extrely difficult to isolate!
Suddenly, the news that Professor Chen isolated this polyrase spread throughout the research institute!
Everyone was absolutely shocked!
How could Professor Chen have such talent in the scientific field?
Creatively inventing a technique called “foam separation.”
Suddenly, Chen Cang’s reputation soared once again.
But the most important thing isn’t Chen Cang’s fa.
It’s his innovative discovery, directly extracting Poly(ADP-ribose) Polyrase-1!
And this enzy’s research on Parkinson’s is growing day by day!
Soon, Tethys and his team discovered that this polyrase’s main function is, in fact, broadly existing in the cell nucleus to repair DNA!
In a normal state, when the polyrase detects DNA damage, it activates and repairs it!
However, when the pathological environnt causes DNA to not be repairable, this polyrase gets over-activated!
As a result, it leads to neurodegenerative diseases, further aggravates the proliferation of misfolded α-synuclein, and induces Lewy bodies…, thus a series of complex processes leading to exacerbation of Parkinson’s!
This discovery by Tethys made Yang Lan’s eyes light up.
Qi Kai and Yang Lan hurriedly began animal experints!
Animal experintation is a step closer to the right answer!
The generation of theoretical grounds was making this experint increasingly anticipated.
Apparently, once a conclusion is reached, it will surely shock the world.
During the research process!
When Yang Lan and Qi Kai conducted animal experints on Parkinson’s model rats.
They discovered more and more terrifying and even shocking issues!
The human body possesses a rich and complete feedback system.
Yet the special state of Parkinson’s causes the regulation of this polyrase to lose the opportunity for feedback!
Similarly, the existence of this polyrase also exacerbates the increase of misfolded α-synuclein within Parkinson’s patients, further worsening the condition.
What kind of process is this forming!
A vicious cycle!
Exactly!
Parkinson’s removes the restraints on the polyrase.
The polyrase aggravates the misfolded α-synuclein, worsening Parkinson’s!
Thus, it seems to form a closed loop.
And unless one link is broken, this cycle will only worsen.
One week later!
While Chen Cang was at the hospital, Qi Kai directly called him to the research institute!
Handed a docunt to Chen Cang!
“Professor Chen, take a look at this!”
Chen Cang was montarily stunned. After opening it and seeing the title, he froze in place!
“The Neurotoxicity of α-Synuclein!”
Chen Cang quickly began reading.
He was instantly engrossed!
Because Tethys and his team’s research discovered that folded pathological α-synuclein aggregates can spread between brain neurons!
Moreover, these pathological α-synuclein can act like seeds, inducing normal α-synuclein, leading to neurodegenerative diseases!
Seeing this scene, even Chen Cang was dumbfounded!
Qi Kai couldn’t help but say: “Now it’s finally explained why the mortality rate of the Parkinson’s rats has increased!”
“Because the misfolded α-synuclein is contagious!”
“And this polyrase is the key interdiate product!”
Tethys excitedly said: “As long as we solve this polyrase, reasonable inhibition can directly delay the onset of Parkinson’s!”
Zhang Mu shook his head: “Not only that!”
“The most important aspect of Parkinson’s isn’t the late-stage treatnt, but the early prevention!”
Upon hearing this, everyone began to think carefully!
Zhang Mu continued: “This is a vicious cycle!”
“As long as there is folded pathological α-synuclein, various polyrases will surely proliferate, and at the sa ti, polyrase aggravates the folding of α-synuclein!”
“Thus, the key is how to detect the folded α-synuclein as early as possible, and promptly intervene with surgery and dication!”
After Zhang Mu finished speaking, everyone beca excited.
Exactly!
In this way, it seems they have found a good thod to conquer Parkinson’s early.
Treatnt is no longer the goal!
It’s about early detection, early intervention!
“How to examine the folding α-synuclein in the human body?”
“Exactly, how can we detect Parkinson’s in people as early as possible?”
Indeed!
Parkinson’s itself is a symptomatic disease.
It can only be discovered once symptoms appear.
Certainly, it’s unrealistic for everyone to undergo a universal check for α-synuclein, right?
Does this an Parkinson’s can’t be prevented?
Thinking of this, everyone couldn’t help but sigh.
What a pity.
It’s hard to get such a breakthrough.
If early detection was possible, patients would save a lot of trouble.
How can it be detected in advance?
At this mont, Chen Cang’s eyes suddenly lit up.
He thought of a treasure!
The new technology he had sold to Google back then, which also earned Chen Cang 1 billion US Dollars: “Stereotactic Brain Technology!”
This new type of cranial stereotactic technology has a special capability: DTI technology!
That is, Magnetic Resonance Diffusion Tensor Imaging!
It can achieve the observation of tissue integrity and connectivity in living organisms, facilitating the judgnt of the extent and range of white matter fiber bundle damage for various diseases.
It also can respond to subtle brain changes in patients with ntal disorders; furthermore, DTI technology can also display the trajectory of neural conduction tracts within cerebral white matter, enabling detailed imaging of central nervous fibers in the human body.
Under the guidance of DTI technology, the individual variations in Parkinson’s patients can be precisely displayed and located, facilitating three-dinsional image reconstruction surgeries and guiding doctors in performing precise and efficient surgeries.
Chen Cang never expected!
After going around such a big circle.
The core technology was still in his hands!
…
ps: There’s a lot of material to check, unfortunately, I can’t write haphazardly which ans needing to treat every knowledge point seriously.
Resud updating… Thank you all for your support.
Reviews
All reviews (0)