Chen Cang’s words were sothing Qi Kai had never seriously considered before!
If other layn asked, they might even think it childish and laughable.
Because isn’t a disease just these various comprehensive manifestations?
But!
Today is different!
Who is Chen Cang? He is a rising star in the field of neurosurgery and a future pillar of Chinese dicine!
Otherwise, would Xiao Runfang pay such a big price?
What does it an to spare no expense and fully cooperate!
When Qi Kai heard Chen Cang’s words, he started to ponder and reflect!
Static tremor, muscle rigidity, bradykinesia... can they be modeled separately?
What’s the significance of separating them?
Thinking of this, Qi Kai looked at Chen Cang and curiously asked, "Professor Chen, do you think there’s great significance in modeling separately?"
Chen Cang nodded!
He is soone with millions of clinical experiences in human Parkinson’s surgery.
He clearly rembers that for creating lesions targeting Parkinson’s, it’s definitely not just in one place.
It’s necessary to select different areas to establish lesions.
The sa goes for choosing Parkinson’s targets.
The ventral lateral nucleus of the thalamus is effective for tremor and rigidity, but its effect on bradykinesia is uncertain.
The dial part of the globus pallidus is effective for rigidity and bradykinesia, and less so for tremor!
Similarly, even with the ventral interdiate nucleus of the thalamus, the specific position where Chen Cang needs to create lesions is different!
Hearing Qi Kai’s question, Chen Cang nodded and said, "Yes, there are differences!"
"When I perford surgery on a patient, Director Zhou Hongguang himself had Parkinson’s with static tremor of both hands, and I chose the ventral interdiate nucleus of the thalamus, with significant surgical effects!"
"So, I wonder if we could establish so targeted rat models?"
Upon hearing Chen Cang’s words, Qi Kai suddenly understood: "Professor Chen’s idea is very constructive!"
"Let’s go, my workshop is just ahead, co in and have a look!"
Chen Cang nodded, feeling a little excited and expectant.
...
...
After putting on his clothes, Qi Kai said to Chen Cang: "Actually, our modeling process is also based on dical knowledge!"
"Mainly according to the pathological characteristics: the loss of dopamine neurons in the substantia nigra and the appearance of cytoplasmic inclusions – Lewy bodies."
"These interactions cause Parkinson’s to occur, which is actually a result: the balance of acetylcholine and dopamine is disrupted, acetylcholine increases, and dopamine decreases."
Chen Cang nodded.
Chen Cang understood this pathological state.
The current main treatnt plans are dopamine dication or inhibiting the secretion of acetylcholine to form a new balance.
But...
The results are concerning!
As Qi Kai operated, he explained in detail.
"Actually, this instrunt mainly asures dopamine."
"The number and shape of dopaminergic neurons are normal at birth, and they gradually start to decrease selectively in youth. When the amount decreased reaches 50%, various reactions can occur, which can be detected through neurochemistry and neurophysiology thods. Look... this is it!"
"This model can show the formation of Lewy bodies."
"Right, this, we can detect hereditary!"
"This is our unique skill, even those foreigners, even in the US, don’t have such technology!"
...
When introducing the equipnt and achievents, Qi Kai was very excited and proud!
This was his lifelong pursuit.
During modeling, Qi Kai was very ticulous.
An assisting student helped him.
Qi Kai wasn’t struggling much.
The little mouse was already anesthetized, lying there at one’s rcy. Thinking it’d wake up the next morning as a noble Parkinson’s rat, it should be quite happy.
After all, its value increased hundreds of tis!
What a pity.
This was not sothing it could decide.
Qi Kai said: "Currently, we mainly use the thod of injecting 6-hydroxydopamine into the substantia nigra or dial forebrain bundle in rats!"
"This is the classic preparation thod!"
As he spoke, he began to operate.
Afterwards, he continued: "Another thod that’s erged in recent years is called the MPTP gavage thod."
In an afternoon, Chen Cang witnessed several modeling thods!
Director Qi Kai was knowledgeable!
He taught Chen Cang a lot about rat anatomy and physiology pathology.
It was truly beneficial!
When Chen Cang was about to leave, he suddenly delightedly discovered:
His progress bar increased by 1 point!
Although it’s only 1 point.
But this was enough to make Chen Cang happy.
[Parkinson’s progress bar: 28%!]
With the gain, Chen Cang was, of course, overjoyed!
The next day, Chen Cang ca again!
Again, another point!
For several consecutive days, Chen Cang was already able to model simply!
Chen Cang finally extended his knife towards the rats!
At this mont, the rat fell very peacefully.
But...
Along with a crisp notification sound.
Chen Cang delightedly discovered.
His progress bar reached 30!
[Ding! Congratulations, your Parkinson’s progress bar reached 30%, reward obtained: Stereotactic precise injection modeling thod!]
As a series of prompts sounded.
Chen Cang was stunned!
Mod... Model... Modeling!?
Damn it...
What I wanted to achieve wasn’t this thing at all.
Chen Cang felt like crying but had no tears.
I want to save people.
Not mice!
But...
When Chen Cang finished viewing this technology thoroughly, he was directly stunned!
This was not only an animal modeling precision thod.
It was also a human treatnt thod!
This is a thod where both internal and surgical ans are applied.
For modeling, it requires using stereotactic technology to stereotactically inject MPTP (a complex compound, 1-thyl-4-phenyl-1,2,3,6-tetrahydropyridine) into the brain.
Upon learning this, Chen Cang was excited.
Perhaps... this could not only model animals but also be used on humans?!
As usual, Chen Cang curiously asked Director Qi: "Director Qi, if we developed targeted models, such as purely static tremor, pure muscle rigidity, or pure balance disorder rat models, what would happen?"
Qi Kai couldn’t help but smile and said: "This... would be amazing!"
"This would be core technology!"
"If we really achieved that technology, our Parkinson’s research would be elevated a level!"
"It would even accelerate Parkinson’s research directly!"
"This is indeed a historic grand project. After you ntioned it that day, I went back to study it. It’s not impossible, but... it’s too difficult!"
Chen Cang smiled slightly: "Director Qi, look at these few mice, could they all have static tremor, do you believe it?"
...
ps: Thank you, Guoguo Alliance Hierarch, for the 10,000 rewards, thank you!
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